Our ovarian cancer risk quiz was designed based on studies of robust ovarian cancer risk factors. This includes Dr. Barbara Goff’s symptom-triggered screening index, which is associated with ovarian cancer sensitivity of 87%. After they complete the quiz, have them share their results and start the dialogue about their ovarian cancer risk.
Pelvic Mass Assessment.
Roughly 20% of women will develop a pelvic mass in their lifetimes. Imaging, single analyte serum testing, and physical exam are common methods to assess pelvic masses for malignancy. However, multiple studies have shown that these individual modalities can miss many cancers, as the sensitivity of these tests is typically low for early stage cancers, premenopausal patients and certain ovarian cancer subtypes.
CA-125II is commonly thought of as a tool for risk assessment as elevated levels may coincide with the presence of advanced ovarian cancer. However, CA-125II alone is not cleared for use to evaluate ovarian masses prior to surgery. Up to 50% of early stage cancers are not detected by the cancer antigen marker. Rather, the FDA cleared CA-125II for monitoring patients who already have ovarian cancer, to facilitate treatment and cancer surveillance. Multiple studies have shown that CA-125II is currently ordered inappropriately, with only one-third of the tests used as intended.10,11
|ANALYTE(S)||CLINICAL USE||Cancer Type|
|CA-125II||Monitoring disease progression, response to therapy||Ovarian|
|HE4||Monitoring recurrence or progression of disease||Ovarian|
|AFP, LDH, hCG||Aid in diagnosis, management and prognosis||Ovarian (germ cell)|
|CA19-9||Monitoring disease status||Pancreatic|
|CEA||Aid in management and prognosis||Not specified (commonly for colorectal)|
- Carney ME, et al., Gynecol Oncol. 2002 Jan;84(1):36-42.
- Earle CC, et al., J Natl Cancer Inst. 2006 Feb 1;98(3):172-80
- Ueland, FR et al., Gynecol Oncol. 2005 Nov;99(2):400-3
- Goodrich ST, et al., Am J Obstet Gynecol. 2014 Jul;211(1):65.e1-65.e11
- Bristow RE, et al., Gynecol Oncol. 2013;128:252-259
- Timmerman D, et al., Ultrasound Obstet Gynecol 1999;13:11–16
- Levine D, et al., Ultrasound Q. 2010 Sep;26(3):121-31.
- Ueland FR, et al., Obstet Gynecol. 2011;117(6):1289-1297
- Longoria TC, et al., Am J Obstet Gynecol. 2014 Jan;210(1):78.e1-9
- Moss EL, et al., J Clin Pathol. 2005 Mar; 58(3): 308–312.
- Petignat P, et al., Eur J Cancer. 2000 Oct;36(15):1933-7.
- Bristow RE, et al., Am J Obstet Gynecol. 2013 Dec;209(6):581.e1-8
Methods of testing, including OVA1, involve the assessment of multiple analytes together to improve ovarian cancer detection.